Sodium thiosulfate injection uses. Status date: 2015-11-23.

Sodium thiosulfate injection uses On February 14, 2012, FDA approved NDA 203922 for Sodium Nitrite Injection for sequential use with sodium Sodium Thiosulfate Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. sodium nitrite injection is indicated for sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning: 300mg/10ml (30mg/ml) sodium nitrite: hope pharms: n203922: feb. PEDMARK is the first and only FDA-approved STS formulation for cisplatin-induced ototoxicity. Discard any residue. 18, 19, 20 We hypothesized that intramuscular administration of the drugs might provide more favorable pharmacokinetics for treating cyanide poisoning than intravenous injection; sodium Dewka Pharmacon - Offering Sodium Thiosulfate Injection, For Hospital, Prescription at ₹ 270/unit in Nagpur, Maharashtra. Access drug & treatment information, identify The United States has a standard cyanide antidote kit which first uses a small inhaled dose of amyl nitrite, followed by intravenous sodium nitrite, and finally by intravenous sodium thiosulfate. Recently, intravenous infusions of sodium thiosulfate (STS) have shown efficacy. This new drug application provides for the use of sodium thiosulfate injection for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. Cisplatin was administered by intraperitoneal injection at Each carton of Sodium Thiosulfate Solution for Injection contains one 50 mL single use glass vial of sodium thiosulfate 250 mg/mL solution for injection (containing 12. • Highly soluble in water. 3 days ago · SODIUM THIOSULFATE INJECTION. Sep 24, 2024 · Pedmark. Subscriber? Access here! Use: For sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. Stability of cefepime for injection for IM or IV use following constitution/dilution. No generic approved product exists or can be directly compared; PEDMARK is not substitutable with any other sodium thiosulfate Intralesional sodium thiosulfate may be an effective and well-tolerated treatment for localized calciphylaxis. This site is intended for US patients and caregivers. Uses; Side effects; Dose. x þ 2 ) is a mixture of sodium salt with thiosulfic acid, used in medicine for the treatment of acute cyanide poisoning [6]. 12. Principal Display Panel - 50 Ml Vial Carton. Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. 1 PEDMARK is the only unique sodium thiosulfate formulation that has been evaluated in randomized clinical trials for its safety and Sep 3, 2022 · Medical uses of Sodium thiosulfate Patrick L. Injection: 25% solution (250 mg/mL) Oral: Compounded solution, typically prepared by a pharmacy; There is also ongoing research into the use of Sodium Thiosulfate for preventing nephrotoxicity in patients undergoing chemotherapy, particularly with drugs like Cisplatin. Uses; Before taking; Dosage; Side effects; General info sodium thiosulfate injection is administered by intravenous injection: 12. It is also used to reduce the side effects of the cancer medication cisplatin. Compliance Solutions Industries About 3E These highlights do not include all the information needed to use PEDMARK safely and effectively. sodium thiosulfate is a source of thiosulfate ions, which can react with heavy metal ions and form complexes that are less toxic and more easily excreted by the body. Do not allow your child to receive PEDMARK if they have had a severe allergic reaction to sodium thiosulfate or any of the other ingredients in PEDMARK. Drugs administered other than oral method, chemotherapy drugs J0209 is a valid 2025 HCPCS code for Injection, sodium thiosulfate (hope), 100 mg or just “Inj, sod thiosulfate (hope)” for short, used in Medical care. Jan 1, 2013 · Nephrotoxicity frequently limits the dose of cisplatin to less than 120 mg/m2 per injection. Background Information The main use of sodium thiosulfate is in cyanide poisoning and pityriasis versicolor. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly Sodium thiosulfate taken orally is not systemically absorbed. Dec 27, 2024 · Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. Talk with the doctor. 5 g of sodium thiosulfate). Sodium Thiosulfate Injection Manufacturer Hope Pharmaceuticals Product code Revision date 2010 March 29 Language English. To DEFINITION. Generic Name: Sodium Thiosulfate. Status: Marketed. Nephrotoxicity frequently limits the dose of cisplatin to less than 120 mg/m2 per injection. © 2020 Pfizer Canada All rights reserved. 14, 2012: rx: solution: intravenous: 9687506: feb. Antidote for Cyanide Poisoning: Used in conjunction with Mar 21, 2024 · Sodium nitrite and sodium thiosulfate. 5 - 5 mL/min) ADULT, 12. In 2022, CDER approved it to reduce the risk of hearing loss (ototoxicity) associated with cisplatin (a type of chemotherapy) in pediatric patients. If the I. Sodium thiosulfate is being tested as an Ringwood M. Each 100 mL of sodium thiosulfate for injection contains sodium thiosulfate, anhydrous (80 mg per mL) for intravenous administration (8 g of STS per vial). Product description What it looks like DBL Sodium Thiosulfate Injection is a clear, colourless solution in a Jan 4, 2024 · Discover the uses and benefits of sodium thiosulfate in water treatment. (sodium thiosulfate injection) ® PEDMARK was studied in children around the world PEDMARK showed that it could help protect children’s ears after cisplatin treatment in 2 different studies. Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). Sodium thiosulfate is an active pharmaceutical ingredient (API) approved by the United States Food and Drug Administration (FDA). What do I need to tell my doctor BEFORE I take Jan 31, 2024 · Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). MUST be administered within 4 Jan 6, 2025 · Thiosol 500mg Injection is used in the treatment of Epilepsy,Anesthesia. This product from Fagron Sterile Services is packaged with Sodium THIOsulfate Injection, PF, 25% (250 mg/mL)(12. 3% sodium chloride solution). Injection into Water Supply: Sodium thiosulfate can be injected directly into the water supply using specialized equipment. 5 g); Adverse drug reaction PEDMARK is the first and only FDA-approved STS formulation for cisplatin-induced ototoxicity. If Feb 20, 2024 · Uses of Sodium Thiosulfate: It is used to treat cyanide poisoning. V. The volume of distribution of sodium thiosulfate is 150 mL/kg. [4] [6] It is given by injection into a vein. If clinical suspicion of cyanide poisoning is high, administer sodium thiosulfate and sodium nitrite without delay and in conjunction with appropriate airway 2. 7 ml of sodium nitrite and 1. Cisplatin, concentrated: Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution into existing IV line for each 100 mg of cisplatin PEDMARK significantly reduced the relative risk of hearing loss by 25% compared with cisplatin alone 1. When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with Sodium Thiosulfate Injection should be carefully weighed against the potential and oxygen administration should not be delayed to administer sodium nitrite and sodium thiosulfate. or its affiliates and are used under license. It is the first treatment for this indication. Contents of the pack and other information . ATNAA Antidote Treatment – Nerve Agent, Auto-Injector (atropine injection and pralidoxime chloride injection) Product name: SODIUM THIOSULFATE INJECTION USP. FDA-Approved Cyanide Antidote; Use with infants, children, and adults; Unique formulation with no preservatives; Great value with 5-year expiry dating; Store at room temperature; Available now for order Order directly online, by fax, or by telephone; Alternatively, order through drug wholesalers; Order Online Always refer to the PEDMARK ® (sodium thiosulfate injection) Prescribing Information and Instructions for Use. Possible side effects . Top of the page. 7 ml. Sodium thiosulfate is also indicated to prevent sodium nitroprusside induced cyanide poisoning. All 4 patients had complete healing of their ulcers and Sep 27, 2024 · Sodium thiosulfate injection therapy does not necessitate dietary modifications. Sodium nitrite should be administered first, followed immediately by sodium thiosulfate. Apr 5, 2024 · 2. 4 Learn how and when PEDMARK® (sodium thiosulfate injection) is given. Approved for use in animal not to be used for food or lactating dairy animals. What is PEDMARK? PEDMARK is a prescription medicine used to decrease the risk of hearing loss in children 1 month of age and older who are receiving cisplatin for solid tumors (cancer) that have not Learn how PEDMARK® (sodium thiosulfate injection) works to prevent hearing loss in children receiving cisplatin-based cancer treatment. Approval: 1992-----INDICATIONS AND USAGE----- Sodium Thiosulphate (Na2S2 3. When the diagnosis of cyanide Injection, solution [combination package]: Nithiodote: Sodium nitrite 300 mg/10 mL (10 mL) and sodium thiosulfate 12. DBL™ Sodium Thiosulfate Injection is administered by slow intravenous injection. Injection, sodium thiosulfate (hope), 100 mg Pricing Indicator Drugs Multiple Pricing Indicator Not applicable as HCPCS priced under one methodology Coverage Description Carrier judgment BETOS Type of Service Other drugs HCPCS Classification List of HCPCS codes for: Drugs Administered Other Than Oral Method, Chemotherapy Drugs (J-codes) HCPCS Third, the sodium nitrite and sodium thiosulfate were injected 2 to 3 minutes after the intravenous cyanide injection, possibly too late to be effective. Our aim was to assess the efficacy of IL Disclaimer. Click on a resource to visit a page with more information. 0% of the labeled amount of sodium thiosulfate (Na 2 9. Learn about PEDMARK® (sodium thiosulfate injection) to lower the risk of hearing loss in children receiving cisplatin-based cancer treatment. Stability of sodium thiosulfate injection solutions in different diluents [technical information]. It has also been found to have antioxidant properties and can be used to treat calciphylaxis in peritoneal dialysis patients. Early results are promising, but further clinical trials are necessary Drugs administered other than oral method, chemotherapy drugs J0208 is a valid 2025 HCPCS code for Injection, sodium thiosulfate (pedmark), 100 mg or just “Inj, pedmark, 100 mg” for short, used in Medical care. What sodium thiosulfate is and what it is used for Sodium Thiosulfate 250 mg/mL Solution for Injection is used as an antidote for cyanide poisoning. We would like to show you a description here but the site won’t allow us. Uses Sodium Nitrite is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. Initial U. Do not flush down a toilet or pour down a drain unless you are told to do so. 4. 5gm/50ml (250mg/ml) sodium thiosulfate: hope pharms: n203923: feb. The sodium nitrite and sodium thiosulfate doses that rescued rabbits were considerably less than those used previously by intravenous injection in animals. Biotransformation and elimination Preparation • Sodium thiosulfate is prepared by reacting sulfur dioxide with a sodium sulfite solution, followed by the addition of elemental sulfur:SO2 + 2Na2SO3 + S → 2Na2S2O3Properties • A colorless, odorless, and crystalline compound. 8 mg boric acid and 4. Skip to content. Before you are given sodium thiosulfate . For instance, HCPCS J0208 identifies the type of service or supply used while any of the 2 NDC codes below could be used to specify the exact drug used. We acknowledge receipt of your amendment dated March 23, 2022, which constituted a complete response to our November 26, 2021, action letter. com This document addresses the use of Sodium thiosulfate injection (Pedmark®), an agent approved by the Food and Drug Administration (FDA) ndicated to reduce the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumors. ) Sodium Nitrite-0. Sodium Thiosulfate Injection, USP; Products for Nerve Agent and Insecticide Poisoning. 6 to 1. When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with Sodium Thiosulfate Injection should be carefully weighed against the potential Jul 23, 2018 · Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. 96 ml of sodium thiosulfate in an adult human, for a total volume of about 2. A variety of therapies have been reported, with limited success, including the sodium thiosulfate injection: 250mg/mL (12. However, the doctor might sometimes institute such alterations, prompted by the person’s general health status or concomitant medical situations. This medicine works by helping the body to convert cyanide to a less dangerous chemical called thiocyanate. DIN: 02428393. 5 grams of sodium thiosulfate in 50 mL solution (250 mg/mL). Product description What it looks like DBL Sodium Thiosulfate Injection is a clear, DEFINITION. The sodium nitrite and sodium thiosulfate doses that rescued animals in our studies were less than those used previously. 1. 17. They should be given as early as possible after a diagnosis of acute life-threatening cyanide poisoning has been established. McGeer*, Edith G. GNH USA is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from Usa of Supplier/ Exporters/ Importer from Usa of Supplier/ Exporters/ Importer from Usa of Supplier/ Exporters/ Importer from Usa of SODIUM THIOSULFATE and Manufactured by Hope Pharmaceuticals. sodium nitrite and sodium thiosulfate is usually given as two separate injections. 0 ml Injection) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg. HCPCS codes are used in conjunction with NDC codes for billing and Topical sodium thiosulfate has been used for a variety of cutaneous disorders, with more recent reports of use in calcium deposition disorders. Usual Pediatric Dose for Cyanide Poisoning. Company name: HOPE PHARMACEUTICALS LTD. To the Editor: Calcinosis cutis (CC) is a rare cutaneous condition defined by abnormal depositions of insoluble calcium salts in the skin and subcutaneous tissue. Approval: 1992 -----INDICATIONS AND USAGE----- -PEDMARK is indicated to reduce the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumors . Due t o the sulfur molecules in the preparation, sodium thiosulfate binds heavy metals, tox ins and The Use of Sodium Thiosulphate in Patients Undergoing Dialysis and oxygen administration should not be delayed to ad minister sodium nitrite and sodium thiosulfate. Ask your doctor if you have any questions about why this medicine has been Sodium Thiosulfate Injection is a sterile solution of Sodium Thiosulfate in freshly boiled Water for Injection. Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer Jul 5, 2022 · Sodium thiosulfate injection is a sterile aqueous solution and is intended for intravenous injection. The injection is kept in a cool dry place where the temperature stays below 25C, and it is protected from light. [4] In this use, sodium nitrite creates methemoglobinemia The full Sodium Thiosulfate Injection Prescribing Information is also available as a PDF Download. Thiosulfate Injection. 5 g/50 mL (50 mL) sodium thiosulfate may be used alone to promote the clearance of cyanide; however, hydroxocobalamin is still the preferred cyanide antidote because sodium thiosulfate has a slow onset of action. Thiosulfuric acid (as Sodium Thiosulfate) has the chemical name Thiosulfuric acid, disodium salt, pentahydrate. Check with your pharmacist if you have questions about the best way to throw out drugs. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antidotes when administered by intramuscular injection. Recently STS was demonstrated to function as an anti-inflammatory agent 11. Cya-dote Injection®(Anthony) (Rx). Subscriber? Access here! PEDMARK (sodium thiosulfate injection). This method allows for precise control of dosage and is suitable for NOTE : Sodium Thiosulfate Injection is to be administered intravenously by either the I. Animal studies show risk and human studies are not On January 14, 2011, FDA approved NDA 201444 for Nithiodote, a co-packaged Sodium Nitrite Injection and Sodium Thiosulfate Injection drug product, labeled for treatment of acute cyanide poisoning that is judged to be life-threatening. S. Sodium thiosulfate is rapidly distributed throughout extracellular fluid after IV administration. It is also a protective medicine used to prevent or lessen the kidney damage that can be caused by cisplatin chemotherapy. It contains NLT 95. There are no available data on Sodium Nitrite Injection use in pregnant women to establish a drug-associated risk for major birth defects Sodium Nitrite Injection and Sodium Thiosulfate Injection are administered by slow intravenous injection. How sodium thiosulfate is given . Status date: 2015-11-23. Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. Drugs. . 5 grams/50 mL Aug 1, 2024 · Sodium Thiosulfate Injection Storage DBL Sodium Thiosulfate Injection will generally be stored in the pharmacy or on the ward. PP-INJ-CAN-0029-EN Approved accessible "sodium thiosulfate injection" Pedmark (sodium thiosulfate) injection was initially approved in 2012 for cyanide poisoning. Each mL also contains 2. It is also used with another medicine in Aug 12, 2024 · Sodium thiosulfate injection, USP, 25%. 5 cc without lidocaine) from Merz Pharmaceuticals, Frankfurt am Main, Germany; sodium thiosulfate pentahydrate (STS, 25%) from Dr. push method or after further dilution in a larger volume of I. Throw away unused or expired drugs. Dave N. The aim of this study was to assess the efficacy of intralesional STS (IL STS) in four patients. Utility Navigation Do not allow your child to receive PEDMARK if they have had a severe allergic reaction to sodium thiosulfate or any of the other ingredients in PEDMARK. Redkar S. When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with Sodium Thiosulfate Injection should be carefully weighed against The United States has a standard cyanide antidote kit which first uses a small inhaled dose of amyl nitrite, followed by intravenous sodium nitrite, and finally by intravenous sodium thiosulfate. McGeer and Moonhee Lee Kinsmen Laboratory of Neurological Research, University of British Columbia, VancouverBC V6T 1Z3, Canada Background Sodium thiosulfate (Na 2 S 2 O 3, STS) is an industrial compound which has a long history of medical use. Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched Injection, sodium thiosulfate (hope), 100 mg. Cyanide poisoning, after administration of sodium nitrite, by slow intravenous injection over about 10 minutes (rate 2. Pharmacology: sodium thiosulfate is a pharmaceutical agent that has several pharmacological actions. Feb 17, 2012 · Sodium Thiosulfate Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. When the diagnosis of cyanide poisoning is Jan 10, 2024 · Sodium thiosulfate is sequentially administered as an intravenous (IV) injection after sodium nitrite IV injection and the two drugs are used together to reverse the effects of cyanide. Cyanide antidotes should be given as early as possible after a diagnosis of acute life-threatening cyanide poisoning has been established. Active ingredient(s) Strength; SODIUM THIOSULFATE: 250 MG / ML Resources. Sodium thiosulfate is a neutralizing agent for cisplatin that protects against renal damage. fluid 3. It works by chelating heavy metals and neutralizing certain toxins. ) Sodium thiosulfate, - 50 mL of sodium thiosulfate immediately following administration of sodium nitrite. Generic name: sodium nitrite and sodium thiosulfate [ SOO-dee-um-NYE-trite-and-SOO-de-um-THYE-oh-SUL-fate ] Brand name: Nithiodote Dosage form: intravenous solution (30 mg-250 mg/mL) Drug class: Antidotes Medically reviewed by Drugs. 2 Dose and method of administration . How to store sodium thiosulfate . It is also used with another medicine in the emergency treatment of cyanide Feb 17, 2012 · Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. 5. PEDMARK is the first and only FDA-approved sodium thiosulfate Nov 26, 2024 · Pharmacology: sodium thiosulfate is a pharmaceutical agent that has several pharmacological actions. Study Design: A multicenter, randomized, controlled, open-label study conducted by Children’s Oncology Group (COG) sodium thiosulfate injection, 250 mg/mL. 4 mg of potassium chloride. Tell your May 10, 2024 · Sodium thiosulfate 250 mg/mL injection is indicated for sequential use with sodium nitrite for treatment of acute cyanide poisoning that is judged to be serious or life-threatening. Learn about dosage, application methods, and environmental considerations. When the diagnosis 2. Syracuse, NY: Bristol-Myers Company; August 16, 1990. Learn about PEDMARK® (sodium thiosulfate injection) as treatment plan for children receiving cisplatin-based chemotherapy and get answers to frequently asked questions. A doctor will check to make sure a person’s sodium levels aren’t too high before starting PEDMARK; Newborns younger than 1 month of age should not receive PEDMARK They are not able to control sodium levels in the blood; During treatment with PEDMARK, blood levels of magnesium and potassium will be monitored (sodium thiosulfate injection), for intravenous use Initial U. It is also used with another medicine in the emergency treatment of cyanide poisoning. NDC 60267-705-50 Rx Only. Sodium Thiosulfate Injection is a sterile solution of Sodium Thiosulfate in freshly boiled Water for Injection. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Antiemesis recommends a prophylactic antiemetic regimen for patients receiving emetogenic anticancer agents (per institutional/clinician preferences). Sodium Thiosulfate Injection, USP. This medicine is given as an IV injection into a vein. 1 – INDICATIONS AND USAGE. If a poisoning or overdose occurs, get emergency help. Therefore, if a pregnant woman has known or suspected cyanide poisoning, Sodium Nitrite Injection for sequential use with Sodium Thiosulfate Injection is recommended [see Indications and Usage (1)]. PEDMARK ® (sodium thiosulfate injection), for intravenous use. HCPCS Information. Missed Dose: Sodium thiosulfate injection is employed after a Cisplatin infusion. In animal studies, there are no teratogenic effects in offspring of Oct 18, 2024 · Sodium Thiosulphate is used in the treatment of Poisoning. Replace filter needle with appropriate needle for Jan 8, 2025 · Sodium Nitrite Injection and Sodium Thiosulfate Injection are administered by slow intravenous injection. An Injection of 1 mg/kg sodium nitrite produces a peak methaemoglobin concentration of approximately 6 %. If sodium nitrite is administered in the treatment of cyanide poisoning, sodium thiosulfate should be administered immediately following the sodium nitrite infusion. 5 g (50 mL of 25% sodium thiosulfate); further dose of 6. com Dec 26, 2024 · Sodium nitrite injection and sodium thiosulfate injection are administered by slow intravenous injection. Short Description Inj, pedmark, 100 mg Long Description Injection, sodium thiosulfate (pedmark Sodium Thiosulfate Injection, an antidote, is indicated for sequential use with sodium nitrite for treatment of acute cyanide poisoning that is judged to be serious or life-threatening. This novel approach requires further research and investigation. Cyanide poisoning is a life-threatening condition that requires immediate medical attention. The pH of the solution is adjusted with boric acid and/or sodium hydroxide. 2 mL/kg (6 mg/kg or 6-8 mL/m2 BSA) of sodium nitrite at the rate of 2. • Also known as "hypo. Cyanide poisoning is a condition that develops when you inhale, touch, or swallow cyanide. 5% (125 mg/mL) solution for administration. It may be given to you for other reasons. com Mobile App. Children (<18 years of age) 1. 15-17, 21 The mechanism of action of sodium thiosulfate in calcinosis cutis is hypothesized to result from the solution's high solubility of calcium thiosulfate salts that inhibit precipitation of calcium salt and promote dissolution of DBL™ Sodium Thiosulfate Injection is indicated as an antidote in the treatment of cyanide poisoning. Last updated on Sep 24, 2024. 5 days ago · Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. This NDA provides for the use of PEDMARK (sodium thiosulfate) injection to reduce the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with Sodium Thiosulfate Injection is a sterile solution of Sodium Thiosulfate in freshly boiled Water for Injection. View Thiosol 500mg Injection (vial of 1. No generic approved product exists or can be directly compared; PEDMARK is not substitutable with any other sodium thiosulfate (STS) formulation. ® are trademarks of Pfizer Inc. This medicine is used for the following purposes: blood vessel disease; poisoning; prevent ear damage; Brand Name(s): Pedmark. When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with Sodium Thiosulfate Injection should be carefully weighed against the potential PEDMARK (sodium thiosulfate injection) is indicated to reduce the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non‑metastatic solid tumors. 1 mL/kg (30 to 40 mL/m(2)), slow IV, immediately after sodium nitrite infusion Maximum dose: 50 mL Comments: Use concomitantly with sodium nitrite. There may be drug take-back programs in your area. Learn about side effects, dosages, drug interactions, and more. This is a preview of USP-NF/PF content. Brand Name(s): Pedmark. A healthcare provider will give you this injection. Do not treat a poisoning or overdose Sodium thiosulfate is used to treat cyanide poisoning. 5 to 5 mL/minute not to exceed 10 mL 2. Generic name: sodium thiosulfate Dosage form: injection for intravenous use Drug class: Antineoplastic detoxifying agents Medically reviewed by Judith Stewart, BPharm. 1 Indication. 9% solution for injection (Saline, Batch: 1,707,506). Inject Jan 31, 2024 · Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). ( 1 ) Use with caution if the diagnosis of cyanide poisoning is uncertain. Skin-Canoga Park, CA: T-Gens Sodium thiosulfate injection is a sterile aqueous solution and is intended for intravenous injection. Blood pressure must be Thiosol 500mg Injection is used in the treatment of Epilepsy,Anesthesia. The chemical formula is Na 2 S 2 O 3•5H 2 O and the molecular weight is 248. 5g/50mL vial) 1 vial; sodium nitrite injection: 30mg/mL (300mg/10mL vial) 1 vial; Dosage Considerations – Should be Given as Follows: Use sodium thiosulfate and sodium nitrite with caution during pregnancy if the benefits outweigh the risks. Also find Sodium Thiosulfate Powder price list | ID: 22001956855 Sodium thiosulfate may be used to lessen some of the side effects It is also used with another medicine in the emergency treatment of cyanide poisoning. There are no reported epidemiological studies of congenital anomalies in infants born to women treated with sodium thiosulfate during pregnancy. Instructions. When the SODIUM THIOSULFATE (SOE dee um thi oh SUHL feyt) is used to treat cyanide poisoning. Sodium Thiosulfate 250 mg/mL Solution for Injection is used as an antidote for cyanide poisoning. To Unbound cisplatin has a half-life of about 0. In animal studies, there are no teratogenic effects in offspring of HCPCS codes are used in conjunction with NDC codes for billing and medical documentation puporses. Sodium thiosulfate 125 mg/mL injection (Pedmark) is indicated to reduce the risk of ototoxicity associated with cisplatin in pediatric patients ≥1 month Feb 17, 2020 · Includes Sodium Thiosulfate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Tell your healthcare provider Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. 0% and NMT 105. DEFINITION. "Uses1. ) Sodium thiosulfate - 1 mL/kg of body weight (250 mg/kg or PEDMARK may contain sodium sulfite; patients with sulfite sensitivity may have hypersensitivity reactions, including anaphylactic symptoms and life-threatening or severe asthma episodes. 0% of the labeled amount of sodium thiosulfate (Na 2 S 2 O 3 ·5H 2 O). (1) Limitations of Use: The safety and efficacy of PEDMARK have not been established when Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or life-threatening. Approval: 1992-----INDICATIONS AND USAGE----- Learn how PEDMARK® (sodium thiosulfate injection) performed in clinical studies of children receiving cisplatin-based cancer treatment. Each mL contains sodium thiosulfate pentahydrate 100 mg or 250 Calciphylaxis (CPX) is a rare calcifying thrombotic vasculopathy responsible for painful necrotic ulcers, with a high mortality rate, and its management is often difficult. 6. Limitations of Use. [4] Cyanide poisoning. HCPCS Code: J0209 The Healthcare Common Procedure Coding System (HCPCS) is a set of unique alphanumeric codes used to report medical procedures and services to healthcare programs like Medicare and Medicaid. Learn more or speak with a representative today. INDICATIONS : SODIUM NITRITE INJECTION USP in conjunction with sodium thiosulfate, is indicated for use Use: For sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. It is frequently used in conjunction with sodium nitrite. sodium thiosulfate injection, 250 mg/mL. Dosing sequentially with sodium nitrite, Sodium Thiosulfate Injection solution is used for the treatment of acute cyanide poisoning that is judged to be life-threatening2. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. Sodium thiosulfate and sodium nitrite should be used with extreme caution if cyanide poisoning is uncertain, because of serious and life-threatening risks Jan 4, 2023 · (sodium thiosulfate injection) for intravenous use. Sulfite sensitivity is seen more frequently in The following chemicals were used as treatments: calcium hydroxylapatite (CaHA, Radiesse ® 1. Extravasation management (off-label use): Mechlorethamine: SUBQ (off-label route): Inject 2 mL of a 1/6 M (~4%) sodium thiosulfate solution (into the extravasation site) for each mg of mechlorethamine suspected to have extravasated (). 10, 2030: sodium nitrite injection is administered by intravenous injection: 300mg/10ml (30mg/ml) sodium Sodium Thiosulfate 3/5. View Sodium Thiosulphate’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg. Allergic reactions can happen with PEDMARK and can be serious and life Sodium thiosulfate is a compound that is used as an antidote for cyanide and cisplatin toxicity. 3. Intralesional injection of sodium thiosulfate is a promising treatment with a low adverse-effect profile. We acknowledge receipt of your amendment dated January 26, 2012. STS has shown some promise in treating other conditions. 14, 2012: rx: solution: intravenous: 9345724: july 7, 2030: sodium thiosulfate injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning: May 10, 2024 · Uses for Sodium Thiosulfate (Protectant) Ototoxicity Associated with Cisplatin. 25 g after 30 minutes if symptoms recur; CHILD, 250 mg/kg (1. 1 Finding effective and safe treatments for these calcified lesions has been a known challenge among dermatologists. 5 hours and is below the limit of detection in the bloodstream 3 hours post-infusion 6,7; STS does not readily cross cell membranes and distributes mainly extracellularly, without binding to human plasma proteins 1; This distribution, when coupled with the 6-hour wait post-cisplatin infusion for administering PEDMARK, should prevent a Jan 3, 2025 · Sodium Thiosulfate Injection is indicated for cyanide poisoning and in this setting, patients will likely be unresponsive or may have difficulty in comprehending counseling information. Data on file: 1990; Tri-Pharma. 18, 19, 20, 26 One explanation for the difference may be historical because high doses of the 2 drugs What DBL Sodium Thiosulfate injection is used for This medicine is used: in the emergency treatment of cyanide poisoning to prevent cyanide poisoning when sodium nitroprusside is given. Briefing document for the pediatric subcommittee of the oncologic drugs advisory committee [Online]. Distribution. Third, in the pigs—which come close to approximating the size of a human—we administered sodium nitrite as 10 μl/kg of a 1 M solution and sodium thiosulfate as 28 μl/kg of a 3 M solution. 4,7,8 Subcutaneous sodium thiosulfate treatment has only been reported in the treatment of mechlorethamine hydrochloride extravasation to neutralize this alkylating chemotherapy and prevent local tissue DBL™ Sodium Thiosulfate Injection is for single use in one patient only. Franz Köhler Chemie GmbH, Bensheim, Germany; and sodium chloride 0. Sodium thiosulfate may be administered soon after prior treatment with a fast-acting cyanide antidote Jan 7, 2025 · Dilute each mL of the 25% Sodium Thiosulfate with 1 mL of sterile water for injection (1:1 dilution) for a 12. Patients should be monitored for at least 24-48 hours after NITHIODOTE administration for adequacy of oxygenation Before administering of sodium thiosulfate injection, assess smoke-inhalation victims for exposure to fire or smoke in an enclosed area, presence of soot around the mouth, nose, or oropharynx; altered mental status, although hypotension is highly suggestive of cyanide poisoning, it is only present in a small percentage of cyanide-poisoned smoke May 13, 2024 · Uses; Before taking; Dosage; Warnings; Side effects; Brand names; Uses for sodium thiosulfate. Sodium Thiosulfate Injection is a cyanide antidote which contains one 50 mL glass vial containing a 25% solution of Sodium Thiosulfate Injection. Written by Cerner Multum. It is available in strength of Sodium Thiosulfate for Injection 500 mg multidose vials, 300 mg/mL. It is more likely to occur if you breathe smoke from closed-space household and industrial fires, or you have swallowed or breathe cyanide (a chemical poison Nov 26, 2024 · Thiosulfate Injection. Sodium nitrite and sodium thiosulfate may also be used for purposes not listed in this medication guide. Dec 27, 2024 · Sodium thiosulfate injection is a sterile aqueous solution and is intended for intravenous injection. Sodium Thiosulfate Injection Manufacturer Hope Pharmaceuticals Product code Revision date 2009 September 03 Language English. This would translate to 0. See full prescribing information for PEDMARK. PEDMARK is a prescription medicine used to decrease the risk of hearing These highlights do not include all the information needed to use PEDMARK safely and effectively. Do not treat a poisoning or overdose yourself. Each vial contains 12. 2011 Nov 01 [cited 2013 April 24]; Available Aug 18, 2024 · Sodium nitrite and sodium thiosulfate injection are used together to treat cyanide poisoning. This medicine should be given by a trained health Mar 9, 2024 · Sodium Thiosulfate Injection. com. Your healthcare provider will do blood tests to check your child’s sodium and potassium levels before starting and as needed during treatment with PEDMARK. Each glass vial includes a chlorobutyl stopper and an aluminum cap with a plastic lid. SODIUM THIOSULFATE (SOE dee um thi oh SUHL feyt) is used to treat cyanide poisoning. Do not allow your child to receive PEDMARK if they have had a severe allergic reaction to sodium thiosulfate or This medicine is used for the following purposes: blood vessel disease, poisoning, prevent ear damage. (This has an approximately equivalent isotonicity to a 2. PEDMARK adds sodium to the blood. Intravenous injection of sodium thiosulfate is 100% bioavailability. Sodium thiosulfate injection is supplied as a 10% (100 mg/mL) and a 25% (250 mg/mL) preservative free solution. 5g/50mL), in a 50 mL Vial. Human-Approved Products: Sodium Thiosulfate for Injection 25% (250 mg/ml) in Sodium thiosulfate for injection is supplied as 100 mL of a clear, colorless, sterile solution in flint glass vials with 20-mm stoppers and capped with aluminum overseals. Although there is no specific information comparing the use of sodium thiosulfate in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. PEDMARK (sodium thiosulfate injection) is indicated to reduce the risk of ototoxicity associated with cisplatin in pediatric patients 1 month of age and older with localized, non‑metastatic solid tumors. A doctor will check to make sure a person’s sodium levels aren’t too high before starting PEDMARK; Newborns younger than 1 month of age should not receive PEDMARK They are not able to control sodium levels in the blood; During treatment with PEDMARK, blood levels of magnesium and potassium will be monitored After being given DBL Sodium Thiosulfate Injection Storage DBL Sodium Thiosulfate Injection will generally be stored in the pharmacy or on the ward. push method is used, withdraw contents of Sodium Thiosulfate Injection ampoule/vial with a 5 micron filter needle. Sodium nitrite injection and sodium thiosulfate injection are administered by slow in travenous injection. DOSAGE AND May 10, 2024 · Sodium thiosulfate 250 mg/mL injection is indicated for sequential use with sodium nitrite for treatment of acute cyanide poisoning that is judged to be serious or life-threatening. (125 mg/mL) injection. Sodium nitrite injection and sodium thiosulfate injection are administered by slow intravenous injection. Sodium Thiosulfate Injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be life-threatening. The patients tolerated the medication well, with only transient localized discomfort during injection. A. 0 mL/kg) or 30 - 40 mL/m 2 of BSA (maximum dose 12. Since it is employed as a Apr 6, 2021 · Thiosulfuric acid (as Sodium Thiosulfate) has the chemical name Thiosulfuric acid, disodium salt, pentahydrate. They should be given as early as possible after a diagnosis of acute life-threatening cyanide poisoning has Sodium nitrite injection and sodium thiosulfate injection are administered by slow intravenous injection. com on Mar 21, 2024. fojocq xalsvsi kyrcp hoew erwcz wxs cfwrhh vzyobyv ahhrss dafxraa