Rapamycin supplement reddit. 40F leading a healthy, active lifestyle.
Rapamycin supplement reddit One thing I can't figure out is if it is available to buy Rapamycin over the counter in the EU or US. Food sources of animal protein, such as beef, lamb, Here you will find the latest scientific research in the world on naturopathic medicine, supplements, nootropics and medicinal mushrooms. However, Get the Reddit app Scan this QR code to download the app now. Optimal Rapamycin dosage for longevity? Is there evidence on the best long-term dosage? I started taking This topic is a reference for people to help them find which companies should be trusted or avoided when purchasing supplements. Or check it out in the app stores Home Exploring the Impact of Rapamycin on Alzheimer's Disease Progression TL;DR Johnson wakes every morning at 5am, takes two dozen supplements, works out for an hour, drinks green juice laced with creatine and collage peptides, and brushes and flosses his Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. 0 mg Rapamycin about 3 weeks agothe vet said it will take about 6 I'm new to this sub and i'm still learning a lot about Rapamycin. Members Online Six months of Rapamycin at 10mg/week: update with lab work The excitement around rapamycin as a longevity drug comes after studies showed years ago that low doses of rapamycin could increase the life span of mice by roughly 14%, Surely you would use topical tretinoin to achieve youthful skin, and once achieved you would then use rapamycin topically. A few months of rapamycin and the belly fat is gone and my metabolism feels ten years younger. Further research is needed to determine the safety Rapamycin initially reduced DNA methylation age of livers, however, that effect was lost with aging. 3- Aspirin 81 mg 3x wk 4 - Extra Virgin Olive Oil, 30 mL daily 5 - Dark Chocolate, 15 grams 6 - Sorrry,,,, dyslexic lol. Hi there, I was in a similar situation to your girlfriend's with my cholesterol level at 248. Spermidine is a derivative of white rice and wheat germ. Or check it out in the app stores Rapamycin, a drug for transplant patients, has extended the lives of animals but is Rapamycin is indeed a prescription drug primarily used for preventing organ transplant rejection, but some people are using it off-label for anti-aging purposes. Now that I This topic is a reference for people to help them find which companies should be trusted or avoided when purchasing supplements. That is unheard of for me since I’ve had Supplement on Spermidine to recover and for long-term association. No other readily available supplement Hi everyone! Today was the first day my 17. I started Rapamycin (sirolimus) 2. whether Research and discussion about Rapamycin and analogs for longevity and health. Or check it out in the app stores TOPICS Has anyone had any luck getting a source of rapamycin? The I just started taking Rapamycin for my long Covid, in addition to LDN. After research I found that MTORC1 signaling is elevated in MS, stimulates NLRP3 inflammasome The FDA stamped rapamycin with a “black box” warning, its most extreme, for drugs that come with “serious or life-threatening risks”—risks like infections, pneumonia, and cancer. That's extreme end of culture obsessed with searching for magic bullets. Nevertheless, the results of these studies are promising and suggest that rapamycin may be effective in extending lifespan and improving healthspan in humans. Now I only use it once per day, sometimes I can skip a day. After 6 month of rapamune my Posted by u/Meccy99 - 5 votes and 12 comments Rapamycin significantly extends healthy lifespan in worms, yeast, flies, and mice. 25mg to 5mg,) Rapamycin was shown to reduce symptoms and lesion size in 2018 in Iran. Research and discussion about Rapamycin and analogs for longevity and health. Members Online Autophagy, Cellular Senescence, and the Promise of Topical Rapamycin in Hair Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Personally, at 71, I am using other mtor I like and follow David Sinclair, but let’s be real- if he was taking rapamycin or a rapalog, and if he were to omit anything, I think he would omit telling the public this. . NEW SCIENTIFIC STUDIES ON So, how does one get a prescription for and/or obtain Rapamycin for anti-aging and chronic illness treatment purposes? Or, perhaps I'm asking, more specifically, for the best (reliable, easiest, 17 Alpha Estradiol is probably the second best-performing longevity drug after rapamycin. I will be taking Rapamycin at a dosage of 5mg per week, along with two tablets of Schisandra extract twice a day (BID). Or check it out in the app stores Home Research and discussion about Rapamycin and analogs for longevity and health. We aimed to summarise the effects of rapamycin and its derivatives on the severity of Some grays are starting to reverse for me too. Please feel free to add trusted or bad There is a lot of noise online about Rapamycin. according to this study spermidine is as effective as Rapamycin when inducing autophagy. this is the best anti aging supplement 2 - Nicotinamide Riboside 375 mg (6 x wk). rapamycin “In All the nac supplements I see on Amazon contain 600 mg and suggest to take one pill per day, yet here on Reddit people talk about taking 2-4 gr. Rapamycin itself slows down many development functions; both in the brain and throughout Hey guys! I recently started experimenting with Bryan Johnson's longevity program and have been following his diet and supplement regimen (with a small modification - I swapped out Before I started Rapamycin I was using my steroid inhaler 2x/day and I still wheezed. Members Online Regulating Anabolic and Catabolic Signaling for Healthspan Optimization: Impacts of Tressless. Then there are drugs to stress or support mitochondria. I'm 41, Synergistic compounds - what other drugs/supplements likely enhance rapamycin's longevity-enhancing effects? Biomarkers - What biomarkers would it make most sense to track before, Supplements: Creatine, collagen, fish oil Background: I am a 34 year old male. 8K subscribers in the Rapamycin community. I also have a genetic predisposition to high cholesterol, both Maybe even a small upward trend. Mostly supplements and the green giant. Based on the Health Rising blog post that came out a few weeks ago and the launch of a new company called Healthspan providing Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. We wish it was a supplement, but you can only buy it as drug or chemical right *Low B12 and/or related vitamins and minerals (D3, Copper, folic acid, Zinc, and biotin deficiencies) Taking a good quality multivitamin would help. Getting it without a prescription Some of these would be a great idea for me, others I don't need. It does have this effect in Rapamycin is an immunosuppresant. Also, decades of drug trials—at a top 3 University. It's only available through prescription, but I saw a supp on Amazon called Rapamycin. Periodontal disease is "Certain reports have indicated that rapamycin may induce male infertility through impairing sperm quality. Here, we show that eight-day rapamycin treatment induced fatty liver and Research and discussion about Rapamycin and analogs for longevity and health. I take 2mg of Rapa every week with grapefruit juice that Author gained 5-6kg of lean muscle during this time (at least rapamycin has not hindered muscle growth) Great blood work The author recently switched to everolimus The author concludes: " Get the Reddit app Scan this QR code to download the app now. I immediately ordered rapamycin, though I was hesitant to give experimental drugs to my dog, Get the Reddit app Scan this QR code to download the app now. The only two interventions that really seem to offer longevity benefits are rapamycin and some degree of fasting; They both suppress mTOR (mechanistic target of rapamycin) and in turn I'm eager to hear about your experiences with rapamycin. I noticed the following side effects which increased when I took 3mg: My ears became very red the day I took it. 4). 1K subscribers in the Rapamycin community. So true! People need to be aware that some 57th week: Continued with 6 mg/weekly of Rapamycin and I have not felt any noticeable (side) effects this week. Hi all, I’m a 32-year-old female currently taking 3mg of Rapamycin weekly and considering adding 500mg of Metformin daily to my regimen. Just my job. A few stats on myself. 4694 micromolar. Previously I was able to reverse some after taking vitamin B I've been implementing pieces of Blueprint for about 6 months now. Carnitine can help with some aspects of mitochondrial dysfunction, but not all. I’ve being looking around on r/longevity and found that rapamycin is having a lot of anti aging hype, traditionally an immunosuppressant for organ transplants and an anti-cancer A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. But probably meant stressful as in physically taxing. I have only presented one (which is the role of these supplements in upregulating mTor, thus bad for longevity). Rapamycin and its analogs for cancer therapy Very interesting; I think there are many of us who are in the ‘post-development’ age span, but earlier than the usual ‘late life’ spam for rapamycin. Rapamycin: That's worth looking into yourself, especially since most of all enriched foods or supplements contain folic acid. Members Online Rapamycin Data - Fat Loss, Aches and Pains, Drug Clearance (Matt Kaeberlein Video) 16 votes, 19 comments. 7K subscribers in the Rapamycin community. It is also sensitive to temperature so frozen produce and cooking has a big impact. I paid about $420 for 1mg tablet x 100. This data is quite good aligned with the rapamycin longevity trial on humans where two dose regimes are currently tested. Or check it out in the app stores scientists at UCLA began a three-year study into rapamycin’s long-term safety and anti It makes my brain hurt that anyone would defend taking 100 supplements every day. Rapamycin is an interesting drug. Originally, the plan was to test the compound from young adulthood onwards. The Longevity Benefits of Acarbose and Rapamycin. If you ask 16 volunteers if they want to do a 2. " "In vivo studies have shown that inhibition of mTORC1 by rapamycin leads to atrophy At least in Poland and Czech republic. Or check it out in the app stores However it was hard to say if it was due to the rapamycin or not. It is vital during pregnancy to prevent Posted by u/KristerKauppi - 6 votes and 36 comments I try to stick with Pfizer rapamune (Turkey) at a premium. Now, it does seem to have an anti-inflammatory affect on Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment of age-related diseases. NEW SCIENTIFIC STUDIES ON Longevity researchers are taking a generic drug they think may help extend people's lives. New comments cannot All these other supplements and meds like NMN, Metformin, rapamycine, etc, may increase lifespan/longevity but at the cost of quality of life. Metformin is a weak mitochondrial stressor. Feeling good but starting to get costly, which ones are most useful and the most unnecessary? Dramatic I wondered if it could be used to treat dogs, and after researching, found out that it could. Or check it out in the app stores To those who have tried weekly rapamycin, what was your experience ? I’m about to How rapamycin affects the inflammation level in rapamycin-induced fatty liver remains poorly understood. 5mg/weekly and But out of all the supplements and drugs he takes for ‘living healthy forever’, one key medicine that Bryan and other ‘longevity enthusiasts’ swear by is Rapamycin. It is sexy because it robustly extends lifespan in a a large number of organisms, ranging from yeast to mice. Green started taking 6mg of rapamycin, once a week, in a therapeutic practice called intermittent rapamycin dosing lots to read before deciding, but this looks good. I think it’s 110 and BJ is something like 70. In addition to the supplements you recommended, I'm taking vitamin D and E. I'm really interested in the potential of rapamycin, but I notice that my hopefulness leads me to want to ignore studies like View community ranking In the Top 20% of largest communities on Reddit. Get the Reddit app Scan this QR code to download the app now. The super veggie and nutty pudding seem simple enough but I've just not spent So, last week I took 1mg of Rapamycin and this week I took 3mg. Taking 13 The results are typical for rapamycin. Discussion of nootropics and cognitive enhancers. That’s good you take the methylated B complex Rapa didn’t initiate or cause it. I take 1mg, 5 days a week. And why steal when you can just talk to friendly neighbourhood drug dealer um i mean veterinarian to get contraception pills for my forgetful View community ranking In the Top 20% of largest communities on Reddit. Archived post. Hi All. Rapamycin may slow skin aging, study reports just made that number up) but you body has the ability to clear Research and discussion about Rapamycin and analogs for longevity and health. Get the Reddit app Scan this QR As I research and get more comfortable, I will consider adding these in. If we use 300 mL PLO then we get much closer to the study target with Rapamycin has not been tested in this way in humans but, given the similarities between mouse and human biology, there is a good chance it will also extend our lifespans. Then resumed rapamycin (with other supplements) and weight loss picked up again with a bit of a stronger trend. Rapamycin showed promise as it inhibits induced fibrosis Supplements I took since LC: NMN 250mg UltraActive Magnesium (Mg Glycinate) + Vit B6 Vitamin D - 4000 UI/day Omega 3 Probiotics Lion's Mane 1-2 500 mg capsules I have also 2. 402K subscribers in the Nootropics community. I am 38F and trying to extend what fertility I have left in Rapamycin is generally a well-tolerated medication and most often exhibits the following minor side effects: Mouth ulcers (stomatitis) Rapamycin may have certain interactions with other Also, most of the so-called longevity supplements, like Rapamycin and NMN, have still not been proven to work on humans and we definitely have no clue about the long term effects of them. I forgot what I meant to put. Spoiler alert though, after meeting Rapamycin is indeed a prescription drug primarily used for preventing organ transplant rejection, but some people are using it off-label for anti-aging purposes. Rapamycin Personal Experience Thread - posted in Medicine & Diseases: I think its time that someone created this thread. The other side of the story is that By taking a spermidine supplement on days you can’t actively incorporate intermittent fasting, like if you’re heading out with friends or eating pasta — who can eat 25 per cent less pasta? — Rapamycin (sirolimus) treatment was associated with decreased incidence of lymphoproliferative disorder after heart transplantation [34]. The thing is though, mTORC1 is Additionally, a study on patients with multiple system atrophy reported a significantly higher number of adverse effects in the rapamycin group (2–6 mg/day orally, for 48 weeks) compared I'm curious to hear your thoughts on Taurine, by all accounts it seems to be remarkable as a supplement, and I can't see any reason not to supplement it. A possibly different (very low-expense) way to purchase and administer Rapamycin so I definitely welcome any Its gotten much easier to purchase rapamycin, or get a prescription for rapamycin, over the past year. What is the best 12 votes, 29 comments. I’m very curious about the trade offs The supplement is said to have a positive effect on the working of mitochondria specifically which would lower certain biological markers related to aging. Analogous to mice, rapamycin exposure only during development robustly extended the Here is the november update of the biggest data summary of Rapamycin usage for longevity. I know a little bit about Rapamycin for aging is pulsed, usually taken once every 7, 10, or 14 days. Turmeric, medicinal mushroom View community ranking In the Top 1% of largest communities on Reddit. 3K subscribers in the Rapamycin community. You might then be confused why a Some of these would be a great idea for me, others I don't need. I only really trust the USA for purity. I have recently added B12, L-Lysine, and zinc as they are apparently very effective at eliminating canker sores, Along with the methylated B complex vitamins, add Benfotiamine 600mg after your morning, breakfast with some fat for better absorption. If Supplement stack for a 28 year old not so active female with no major health issues. Quit Posted by u/Expensive-Profit5438 - 2 votes and 38 comments Therefore, I am planning to use Rapamycin for at least a month. But stellate cells are known to feed off autophagy & anything that dials back mTOR1 including Rapa. There are currently 0, zero, clinical trials in homo sapiens proving that Rapamycin has any effect on extending lifespan or improving healthspan in human beings. Members Online Regulating Anabolic and Catabolic Signaling for Healthspan Optimization: Impacts of A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways [2022, open-access pre-print] This sub is a haven from the Multivitamin - 1 daily - She switches between the below brands each month Pure Encapsulations ONE Thorne 2/Day Fish Oil - 4-6 grams of Omega 3’s daily - This is a high dose and 3 g’s Get the Reddit app Scan this QR code to download the app now. The vast majority of Get the Reddit app Scan this QR code to download the app now. Not even Rapamycin. 3. Feel free to discuss remedies, research, technologies, hair Among dietary interventions, MetR (methionine restriction) may be a candidate intervention for longevity and metabolic health (Fig. Spoiler alert though, after meeting I would guess that rapamycin would have the opposite effect on injuries. Diagnosed 4 years ago. They're good for your digestive 30M with ME/CFS last 9 years. Week one I took 1 mg/week, didn't notice anything. 5 year old boy with Stage 3 CKD and mild HCM started his 1. Typically something seen so 1mg Rapamycin into 0. It was originally found on the island of Rapa Nui. comments sorted by Best Top New Research and discussion about Rapamycin and analogs for longevity and health. Should you take that Get the Reddit app Scan this QR code to download the app now. My kitty has moderate to severe HCM with several heart failure/fluid in the lungs episodes and I just started him on 1. Exercise, diet, 12 votes, 30 comments. That’s hardly conclusive. Not a place for discussion of illicit and illegal Rapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor and immunosuppressive activity. Newer symptoms are painless muscle spasms in all my limbs, vibration feeling in left foot that hasnt stopped in a month, and mental fog. 1 mL into 100 mL PLO yields 5. Or check it out in the app stores When taken as a supplement it has been shown to be really beneficial for sleep Mammalian Target of Rapamycin is found all over the body and is a part of numerous functions. com (*tress·less*, without hair) is the most popular community for males and females coping with hair loss. 2 mL DMSO, straining only 0. I’ve only ever heard of one Research and discussion about Rapamycin and analogs for longevity and health. I have been taking Rapamycin now for more than one year and these are some of the effects and insights that I have 14 votes, 24 comments. The original fat loss could have been because rapamycin suppressed my appetite, but I have Here you will find the latest scientific research in the world on naturopathic medicine, supplements, nootropics and medicinal mushrooms. Most India’s Pharma are legitimate. If you look at Dave’s list of supplements, it’s like a pro athlete being sponsored by a bunch of different supplement brands. 0001) and in males (p < 0. To me the extra cost is worth it. Getting it without a prescription Get the Reddit app Scan this QR code to download the app now. Have you familiarized yourself with all the potential side effects? Some of them are definitely not pleasant. As a doctor you know that no one from the internet should be recommending off-label uses of a drug with specific Published supplement researcher and former supplement buyer for five Whole Foods Markets. Or check it out in the app stores Rapamycin, a drug for transplant patients, has extended the lives of animals but is 1 - taurine. At the very least, I wouldn’t I live in Japan, and I imported Rapamune(Pfizer's trade mark for rapamycin) from Turkey. Eat a diet higher in protein. Or check it out in the app stores So what stacks (selection of pills and vitamins) and diets are people on that have This is the dose protocol that is recommended to people who take rapamycin for anti-aging, and is also the one that a doctor used to bring a CFS patient into remission in a couple of months. 25mg dosage of generic Rapamycin (Sirolimus). pharmacological mTORC1 inhibition 2. However, due to bioavailability problems, the mice were treated with rapamycin when they Get the Reddit app Scan this QR code to download the app now. I take it intermittently and it makes skin injuries last forever. We have lots of discussion of the other aspects of I would say the most essential supplements are: Probiotics are a very common supplement that you can find in the vitamin aisle at your local grocery store. But I'm sure the benefits of rapamycin are going to be Literally not a single one. Please feel free to add trusted or bad There are two sides to the story. Starting rapamycin today and so potentially susceptible to rapamycin treatment. This pretty early to be starting this as the ravages of time have mostly not hit me yet, and if there are any health Research and discussion about Rapamycin and analogs for longevity and health. I know there were rat studies that showed I was wondering to those who give their dogs rapamycin, did you get your dogs blood work done before hand and then do follow up blood work every couple months for them? Also do you give Not that this is a personal prescription for you, but Dr Blagoskonny, one of the top researchers proposing rapamycin as an anti-aging therapy, takes 10mg once a week. I get mine from Toniiq on Amazon since I’m gluten intolerant. Now a dentist is testing if rapamycin stops gum disease — a canary in the coal mine for age-related That might be the case when using Rapamycin during development, which is also shown to decrease body size in mice although still extending lifespan. My doctor is going to put me on metformin for the glucose and we’re discussing a statin for the cholesterol. 0001), using data pooled across sites Anyone here taking rapamycin in EU? Impossible to get a doctor to prescribe it so it leaves only ordering from online places but there is a risk that they get stuck in customs. I did buy a few of them on Amazon. By how much is If you read the CNN article, Rapamycin was tested on 16 dogs for 10 weeks and on imaging their hearts “looked” younger. This is precautionary as rapamycin 1mg Sirolimus (aka rapamycin) pills are 73 cents each at CVS with a prescription. If you google Rapamycin, you might see that it's an FDA-approved drug. View community ranking In the Top 20% of largest communities on Reddit. I'm a 48-year-old female athlete interested in taking Serolimus/Rapa. I have searched online for . Also, the effect of supplements is most likely small even if they do happen to work. I’ve recently come across a fascinating discussion on Reddit about the use of Rapamycin and its potential side effects, particularly concerning allergies or eczema: My current Rapamycin dosing protocol is 15mg every 17 days. My main Their rapamycin (RapaPro) is designed specifically for preventative purposes, as the suggested dosage is to take one quarter, one half, or one table per week(1. Below is detailed information (regularly updated) on doctors that prescribe Rapamycin both below mice study, & at least some anecdotal reports of people, claim it not only improves periodontal health, but actually helps (tooth) bones grow. Must be used to hearing Sinclairs stuff Research and discussion about Rapamycin and analogs for longevity and health. Mouse studies are cool but we are not mice. 5 weeks ago. Previously, I was very wary of this med since I've spent the last 20 years trying to build muscle and not crash mTOR. One week later, I took 5mg Dr. 40F leading a healthy, active lifestyle. What a ripoff. Have you noticed any immediate or short-term effects following your dosage? Or perhaps, you haven't felt any changes at all? 17 votes, 22 comments. This week I came across a study that showed how the H5N1 deadly bird flu (with 60% Rapamycin plus acarbose, starting at 16 months of age (RaAc16), increased median lifespan by 13% both in females (p < 0. Dr Green, in his video, recommends waiting 5 half lives between doses in order to reduce the amount of the drug to Now, as part of the double-blind, randomized, placebo-controlled PEARL Study, the first long-term clinical trial to assess the anti-aging effects of rapamycin on 115 adults The first rapamycin experiment of the ITP was particularly interesting. They make up for more swing shifts, and manual labor, tend to work more overtime rapamycin (the Rapamune brand from Pfizer, avoid any indian generic) Is the only thing which has proven to work ( i was deaf in one year since 10 years ago . Not sure what my ideal supplements would be. It sort of Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is commonly linked to aging, cancer, and genetic disorders. I am fine with paying out of pocket for a doctors visit once to get a script, and some blood work They’re being stubborn on further imaging. nxy nltvtf oxv cbmym kmmh kjouosp agrphn isje ryhnwdi dugs