New lung cancer treatment 2020. 5 per 100,000 population among Asian or Pacific Islanders .
New lung cancer treatment 2020 Lower rates of cancer treatment among Aboriginal people can contribute to this. 14 This study examined receipt of surgery, chemotherapy, and radiation, as reported by cancer registries. As awareness of lung cancer's causes grows, the number of new cases has been declining since Sep 13, 2022 · According to the new findings, capmatinib shrank the tumors of 68% of patients who had not received any previous cancer treatment, and prevented tumors from growing back for a median of 17 months. However, a shift is underway. 17,18 Although programmed death Study design and methods: We used 2015-2020 National Program of Cancer Registry data covering 89% of the US population to describe first-course treatment among people aged ≥ 20 years and diagnosed with lung and bronchus cancer. Smoking is widely recognized as the leading cause of lung cancer. Treating cancer has been a highly complex process. Apr 12, 2024 · But with new treatments and technology, the survival rates from lung cancer are dramatically improving, allowing some patients with relatively late-stage cancers to live for years longer. Food and Drug Administration (FDA) has approved three novel drugs for the treatment of lung cancer, in addition to eight expansions for the use of therapeutics previously approved for other indications. Oct 5, 2024 · The new treatment stopped the disease from advancing for an average of about two years. Dec 12, 2024 · As 2024 comes to an end, we reflect on a year of progress and breakthroughs in non-small cell lung cancer care. Oct 20, 2023 · Tarlatamab, a bispecific T-cell engager immunotherapy targeting delta-like ligand 3 and CD3, showed promising antitumor activity in a phase 1 trial in patients with previously treated small-cell Aug 12, 2020 · According to a new study, mortality rates from the most common lung cancer, non-small cell lung cancer (NSCLC), have fallen sharply in the United States in recent years, due primarily to recent advances in treatment. 1 Risk factors such as smoking, environmental pollutants, genetic predispositions and occupational exposures significantly contribute to the risk of lung cancer. Responses in breast cancer have been more Surgical Treatment Lung cancer can often be treated with surgery if it is diagnosed at an early stage and has not spread. The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progresses in screening, diagnosis, and treatment. The 5-year relative survival rate from 2014 to 2020 for patients with lung cancer was 27%. 2020 Guidelines 2021 Guidelines; Age: The rate of new lung cancer cases is 26. From immunotherapy in the adjuvant setting to the approval of the first-in-class, highly … Apr 25, 2020 · In regard to what is new in targeted therapy, RET fusion and C-met exon 14 skipping are 2 examples of what Spira believes is going to make a difference in lung cancer therapy. Nov 18, 2020 · Lung Cancer 139, 1–8 (2020) New lung-cancer drugs extend survival times How liquid biopsies allow smarter lung-cancer treatment Artificial intelligence is improving the detection of lung Mar 8, 2024 · Centres performing lung resections for lung cancer should validate their data for the Royal College of Physicians Lung Cancer Clinical Outcomes publication and the National Lung Cancer Audit. conducted during 2020-2022 in multiple countries. Aims: To investigate demographic, clinical and access factors associated with lung, breast and bowel cancer treatment for Aboriginal people compared with non-Aboriginal people in New South Wales, Australia. The rate of new cases of lung and bronchus cancer was 49. From 2004 to 2020, most lung cancer drugs approved by the FDA are for the treatment of advanced lung cancer, but few for postoperative adjuvant therapy of early-stage lung cancer, of which the current standard treatment is still chemotherapy 2. , treatment delays, dosing and schedule changes) in more than half of people diagnosed with lung cancer between March and May of 2020 . ) for adult patients with metastatic non-small cell lung cancer (NSCLC Although targeted therapy is standard of care in a large subset of oncogenic addicted non-small cell lung cancers (NSCLC), until recently, this therapeutic approach has not been feasible for all genomic alterations such as for those tumors harboring Epidermal Growth Factor Receptor (EGFR) exon 20 in … Sep 21, 2021 · Spotlight on Small Cell Lung Cancer. Feb 16, 2024 · Treatment with repotrectinib can shrink tumors in people with advanced lung cancer whose tumors have ROS1 fusions. The advances in systemic treatment have been driven primarily by the development of molecularly targeted therapeutics, immu … Nov 13, 2024 · Lung cancer leads in causing cancer-related mortality worldwide, continually posing a significant threat to human health. Whether these improvements translate into the clinic setting has not been studied yet. Spigel from Sarah Cannon Research Institute who presented the pivotal ADRIATIC phase III trial of 528 patients using adjuvant durvalumab with and without tremelimumab as consolidation treatment in patients with limited stage small-cell lung cancer (SCLC)) after chemoradiotherapy. New lung-cancer drugs extend survival times How liquid biopsies allow smarter lung-cancer treatment Artificial intelligence is improving the detection of On February 15, 2024, the Food and Drug Administration granted traditional approval to tepotinib (Tepmetko, EMD Serono, Inc. Kris, MD, of Memorial Sloan Kettering Cancer Center to discuss the recent trends in lung cancer treatment. Lifestyle and home remedies. ctDNA also shows promising applications in adjuvant Abstract. 3 Hospital Universitario 12 de Octubre, CNIO-H12O Lung Cancer Unit, Universidad Complutense and Ciberonc, Madrid, Spain. Early detection and screening for Nov 6, 2020 · New lung cancer treatments lead to vastly improved survival rates 6-Nov-2020 1:45 PM EST, by University of California, Los Angeles (UCLA), Health Sciences contact Nov 18, 2020 · 18 November 2020; Lung cancer. 2020 Guidelines 2021 Guidelines; Age: The rate of new lung cancer cases is 39. LC treatment is associated with huge costs for patients and society; consequently, there is an increasing interest in the prevention, early detection with screening, and development of new treatments. Food and Drug Administration approved Lumakras (sotorasib) as the first treatment for adult patients with non-small cell lung cancer whose tumors have a specific type of genetic Feb 25, 2025 · Targeting two proteins that cancer cells rely on to sustain their metabolism and DNA repair capabilities can double the survival rate of mice with lung cancer tumors. Because Jan 8, 2020 · In 2020, 1,806,590 new cancer cases and 606,520 cancer deaths are projected to occur in the United States. of lung cancer evolves and treatments improve, divergent outcomes between (Cancer Discov 2020; 10:674). May 8, 2024 · The treatment also reduces the risk of the cancer spreading to the brain, a common occurrence in people with lung cancer. Oct 1, 2022 · Despite a global pandemic that continued to inflict chaos and confusion on the world, resulting in fewer cancer screenings and delayed surgeries, remarkable lung cancer treatment advancements were made in 2021. In some cancers, like lung cancer and melanoma skin cancer, immunotherapy has been successful at treating even advanced cancers. Non-Small Cell Lung Cancer Advances Advances in treating stage 1, 2, or 3 NSCLC Oct 26, 2024 · This study describes first-course lung cancer treatment patterns between 2015 and 2020 by sociodemographic characteristics. Data were obtained from PubMed using the search criteria “lung cancer”. Sotorasib is a targeted treatment, specifically for patients whose lung cancer carries a mutation known as KRAS G12C. In general, the earlier that lung cancer is diagnosed, the more likely that treatments will be effective and improve chances of survival. Keywords: Lung cancer, Immune checkpoint inhibitors, Targeted therapy. Oct 30, 2020 · Sonam Puri gets up every day to care for patients with lung cancer. Sep 19, 2020 · Address reprint requests to Dr. growing number of new lung cancer targets are Sep 4, 2020 · According to a new study led by researchers at NCI, mortality rates from the most common lung cancer, non-small cell lung cancer (NSCLC), have fallen sharply in the United States in recent years, due primarily to recent advances in treatment. We retrospectively analyzed all patients cons … Nov 11, 2024 · Lung cancer remains the leading cause of cancer-related deaths worldwide, with over 230,000 new cases diagnosed each year in the United States alone. Rosen (Enid A. Who Gets This Cancer? Lung cancer is more common in men than women, particularly non-Hispanic Black men. 5 times Nov 12, 2024 · Lung Cancer Treatment. 1 per 100,000 population among Asian or Pacific Islanders Nov 18, 2020 · 18 November 2020; New lung-cancer drugs extend survival times. Here are some of the top developments covered by Targeted Oncology TM, highlighting the progress in targeted therapies and improved patient outcomes. The approval was based on the clinical trials co-led by Memorial Sloan Study design and methods: We used 2015-2020 National Program of Cancer Registry data covering 89% of the US population to describe first-course treatment among people aged ≥ 20 years and diagnosed with lung and bronchus cancer. The red arrow indicates the start of the pandemic in 2020. In a paper published in Science in 2016, MSK physician-scientist Piro Lito and Dr. ” This article takes a closer look at stage 4 NSCLC, including Aug 12, 2020 · ONCOLOGY recently sat down with Mark G. Nine people (7%) stopped the treatment because of side effects. Treatments such as supplemental oxygen and medicines are available to help you feel more comfortable. Our study used data available on lung cancer treatment from the Centers for Disease Control and Prevention National Program of Cancer Registries (NPCR). Aug 25, 2020 · In a study recently published in Nature Medicine, 1 Lu et al. 2 Jul 10, 2020 · For people with cancer who have a mental health disorder, getting mental health treatment may help them live longer, a new study suggests. Currently, chemotherapy, targeted therapy, immunotherapy, radiation therapy, and surgery are the most common options of lung carcinoma therapy in Jun 25, 2024 · A collection of material about the ALCHEMIST lung cancer trials that will examine tumor tissue from patients with certain types of early-stage, completely resected non-small cell lung cancer for gene mutations in the EGFR and ALK genes, and assign patients with these gene mutations to treatment trials testing post-surgical use of drugs targeted against these mutations. Anatomy Nov 13, 2024 · Most lung cancer cases are diagnosed at later stages when the cancer has spread to other organs, treatment options are less likely to be curative, and survival is lower. Next at the ASCO plenary was Dr. In the study, of more than 50,000 veterans treated for lung cancer within the Veterans Affairs (VA) system, those living with mental illness who received mental health treatment—including substance use treatment—lived substantially longer than those who Nov 15, 2024 · How is the treatment of lung cancer changing? Exciting new treatments have emerged in recent years — both for early-stage tumors (stage 1, 2, or 3) that can be surgically removed, and for more advanced stage 4 lung cancers that have spread (metastasized). New Therapies for Metastatic Lung Cancer. Pathological diagnosis, the gold standard for confirmation, also faces challenges like Aug 5, 2024 · Over the past 20 years, several innovative therapies have been implemented in the treatment of lung cancer that have had reported survival benefits in clinical trials. Sep 4, 2020 · According to a new study led by researchers at NCI, mortality rates from the most common lung cancer, non-small cell lung cancer (NSCLC), have fallen sharply in the United States in recent years, due primarily to recent advances in treatment. Net Detection Diagnosis Research New organoids facilitate faster study of early lung cancer, potential treatments September 10 2020, by Nancy Fliesler Two lung organoids made from mouse lung cells: a large one and a small one at Sotorasib was developed thanks to years of hard work, much of it done at MSK, including in physician-scientist Neal Rosen’s lab in the Sloan Kettering Institute. The New Era in Lung Cancer Care Oncology (Williston Park) . Then, she carves out time to work with other researchers at Huntsman Cancer Institute to tackle why and how cancer develops in small cell and non-small cell lung cancer patients. Smoking is the leading cause of lung cancer, responsible for approximately 85% of all cases. 6% of cases underwent surgery, which was a 3% improvement over the last five years. The approval was based on the clinical trials co-led by Memorial Sloan Nov 24, 2020 · IMMUNOTHERAPY IS ONE of the most promising new cancer treatments, as it can turn the power of the immune system— more powerful than any cancer drug —against cancer cells. Preliminary results from the full study group, which includes people with several different kinds of cancer, were published September 2020 in the New England Journal of Medicine. 2 The study found that Sep 11, 2024 · “The limited options of treatment for patients with small cell lung cancer is the reality that we all confront — but that is not for lack of trying,” said Dr. Herbst at the Section of Medical Oncology, Yale School of Medicine and Yale Cancer Center, 333 Cedar St. Nationally, 20. Researchers at the University of Cincinnati are studying how a specific gene and fatty acids, called lipids, help fortify lung cancer cells and if targeting the gene and lipids can lead to Apr 30, 2024 · Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. Current imaging diagnostic techniques, while offering non-invasive detection, suffer from issues such as insufficient sensitivity and the risks associated with radiation exposure. Treatments for small cell lung cancer have remained virtually the same for decades. Mar 2, 2025 · New blood test using ctDNA methylation biomarkers shows promise for early lung cancer detection, potentially improving treatment outcomes for patients. May 28, 2021 · Today, the U. 5 per 100,000 population among Asian or Pacific Islanders Apr 12, 2021 · A 2020 research review even states that new treatments are “turning lung cancer from an incurable disease into a chronic disease. , of the Yale Cancer Center, who presented the data on June 4 at the 2023 annual meeting of the American Society of Clinical Oncology (ASCO). 7%), one study observed treatment changes (e. Many people with lung cancer experience shortness of breath. The report finds that Utah has the nation’s best lung cancer rate while Kentucky has the worst at almost 2. Lung cancer is often diagnosed at advanced stages when treatment options are limited. Sotorasib was developed thanks to years of hard work, much of it done at MSK, including in physician-scientist Neal Rosen’s lab in the Sloan Kettering Institute. Feb 26, 2025 · This breakthrough is especially significant considering lung cancer’s status as one of the most common and dangerous cancers worldwide. Cancer is a global health problem responsible for one in six deaths worldwide. In a small number of patients with advanced forms of melanoma, lung cancer, and other tumor types, deposits of cancer scattered throughout their bodies simply melt away. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural While we found that receipt of surgery for lung cancer remained similar in 2019 (23. Tony Mok prefers a more anecdotal indicator to describe the shift in treatment for advanced lung cancer. (C) Visualization of the trend in the number of new lung cancer trials registered on clinicaltrials. However, adjuvant chemotherapy only improves the 5-year survival rate by 5. . Most lung cancer cases are diagnosed at later stages when the cancer has spread to other organs, treatment options are less likely to be curative, and survival is lower. Cross referencing with data from The Cancer Genome Atlas of human tumors suggests that these findings could translate to people. * Progress for hematopoietic and lymphoid malignancies (leukemias and lymphomas) has been especially rapid due to improvements in treatment protocols, including the development of targeted therapies. Taofeek K. Feb 26, 2025 · A class of immunotherapy drugs called immune checkpoint inhibitors have proven transformative for people with some types of cancer. From advancements in screening technology to treatment options, this year has been filled with progress thanks to the collective hard work of patients, advocates, researchers, healthcare teams, and communities. examined the feasibility and safety of using CRISPR-engineered T cells to treat late-stage lung cancer. Lung cancer is the leading cause of cancer-related mortality in the United States. gov each month from August 2019 to April 2022. 1 The assumption by patients and providers that early detection and treatment of recurrence may lead to better Abstract. 2 million incident cases worldwide. Tobacco smoking remains the predominant risk factor for lung cancer development. O. May 24, 2021 · Update: On May 28, 2021, the US Food and Drug Administration granted accelerated approval to sotorasib (Lumakras TM) for the treatment of advanced non-small cell lung cancer driven by the KRAS-G12C mutation in patients who have already received at least one other treatment. 14 Based on this system, approximately 30% of patients with SCLC have LS-SCLC, 40% have ES-SCLC, and the remainder are unclassified. Among those who had already received one or more cancer treatments, capmatinib shrank the tumors of 44% and kept them in check for about 10 months. g. Aug 25, 2020 · Research Highlight; Open access; Published: 25 August 2020 The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer Jan 28, 2025 · Newer treatments target pathways like Delta-like ligand 3, poly-ADP-ribose polymerase, and histone deacetylase to address small cell lung cancer's aggressive nature and resistance to conventional Aug 24, 2024 · 1 Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai Health System, New York City, NY, USA. 14 The International Association for the Study of Lung Cancer Study design and methods: We used 2015-2020 National Program of Cancer Registry data covering 89% of the US population to describe first-course treatment among people aged ≥ 20 years and diagnosed with lung and bronchus cancer. Among females, lung cancer was the leading Dec 12, 2019 · Patients with localized non–small-cell lung cancer (NSCLC) or small-cell lung cancer (SCLC) are treated with intent to cure; however, the optimal surveillance of these patients for cancer recurrence and new primary lung cancers after potentially curative therapy is controversial. Increasing interest in the exploitation of ctDNA as a tool for early cancer detection and improvement of therapeutic outcomes derives from the recent advances in DNA sequencing technologies and from a better understanding of tumor molecular biology. We performed multivariable logistic regression to examine associations between sociodemographic characteristics and Trends in Age-adjusted Cancer Death Rates by Site, US, 1930-2020 For Males (PDF) For Females (PDF) Estimated Number of New Cancer Cases and Deaths, US, 2023 By Sex (PDF) Estimated Number for Selected Cancers by State, US, 2023 (PDF) Of New Cases (PDF) Of Deaths (PDF) Leading Sites of New Cancer Cases and Deaths - 2023 Estimates (PDF) Nov 24, 2020 · IMMUNOTHERAPY IS ONE of the most promising new cancer treatments, as it can turn the power of the immune system— more powerful than any cancer drug —against cancer cells. We performed multivariable logistic regression to examine associations between sociodemographic characteristics and Oct 20, 2023 · Tarlatamab represents a new immunotherapeutic approach for small-cell lung cancer, a tumor type that is characterized by an immunosuppressive microenvironment. FDA approved the drug in 2023 as an initial or second-line treatment for ROS1-positive NSCLC. 3% 3. Now, experts say that hope is on the horizon. Lung Cancer Trial of Osimertinib Draws Praise—and Some Criticism The drug improved survival in a large clinical trial, but some question the trial’s design. D. Box 208028, New Haven, CT 06520, or at [email Jun 25, 2021 · For 28 patients (22%), side effects led to a pause, a reduction, or both, in the dose of sotorasib. Several targeted drugs were approved in 2020 to treat the most common type of lung cancer. Nov 30, 2020 · So far in 2020, the U. 8 million new cancer cases diagnosed and 606,520 cancer deaths in the United States. 0 per 100,000 men and women per year based on 2017–2021 cases, age-adjusted. The red line denotes the official start of the COVID-19 pandemic Jun 26, 2023 · Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for the highest mortality rates among both men and women. Jan 6, 2025 · Significant advancements in lung cancer treatment were seen throughout 2024, from new drug approvals to promising clinical trial results. [2019] For a short explanation of why the committee made these recommendations and how they might affect practice, see the rationale and impact section on Dec 4, 2023 · Australians living with extensive-stage small cell lung cancer, an aggressive and less common form of lung cancer 1, will be able to access a new immunotherapy on the Pharmaceutical Benefits Scheme (PBS) from 1 December 2023 following the PBS listing of IMFINZI® (durvalumab) in combination with chemotherapy for eligible patients. 8%) and 2020 (22. News-Medical. Jul 5, 2023 · The findings “herald a new era of targeted therapy in early-stage [lung cancer],” said the trial’s lead investigator, Roy Herbst, M. Conventional treatment approaches, such as surgery, chemotherapy, and radiotherapy, have been in use, while significant advances are being made in recent times, including stem cell therapy, targeted therapy, ablation therapy, nanoparticles, natural In recent years, the emerging immunotherapies and targeted therapies open up a new realm of precision cancer treatment for lung cancer patients, especially for NSCLC (Siah, Khozin, Wong, & Lo, 2019). Apr 17, 2023 · A new drug called sotorasib which was trialled as a treatment for advanced non-small-cell lung cancer (NSCLC) at The Christie NHS Foundation Trust in Manchester is now available on the NHS. ) Current cancer incidence, mortality, and survival statistics Information on cancer symptoms, risk factors, early Lung cancer currently stands out as both the most common and the most lethal type of cancer, the latter feature being partly explained by the fact that the majority of lung cancer patients already display advanced disease at the time of diagnosis. We discuss recent advances and highlight the plethora of new approvals of molecular-targeted therapy for subgroups of NSCLC patients with sensitizing EGFR, ALK, ROS1, RET, BRAF V600E, MET, and NTRK alterations. Haupt Chair in Medical Oncology) showed how it was possible to block the most common form of mutated KRAS in lung cancer, called KRAS-G12C. 17,18 Although programmed death Small cell lung cancer has traditionally been classified into LS-SCLC or ES-SCLC using the Veterans Administration Lung Study Group staging system. Apr 25, 2022 · A phase 3 trial confirms that addition of the checkpoint inhibitor nivolumab to neoadjuvant chemotherapy improves outcomes in patients with early-stage lung cancer. "Today's FDA approval marks a significant milestone for the SCLC community as the availability of a targeted bispecific Despite advances in our understanding of risk, development, immunologic control, and treatment options for lung cancer, it remains the leading cause of cancer death. Owonikoko, executive director of the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center in Baltimore. Estimated numbers of new cancer cases and deaths in 2020 (In 2020, there will be an estimated 1. Nov 12, 2024 · Lung Cancer Treatment. In recent years, the development of specific tyrosin … May 27, 2022 · Lung cancer (LC) is the second most commonly diagnosed cancer and the primary cause of cancer death worldwide in 2020. Both therapies are known for clinical benefits such as tumor shrinkage and causing fewer adverse effects on patients. A new drug combo can stop lung cancer in its May 16, 2024 · "After decades of minimal advancements in the SCLC treatment landscape, there is now an effective and innovative treatment option available," said Laurie Fenton Ambrose, co-founder, president, and CEO of GO2 for Lung Cancer. Jan 31, 2020 · ctDNA and CTCs: two complementary strategies to decipher the complexity of advanced cancer. "People are donating $5 for somebody who has Nov 12, 2024 · Most lung cancer cases are diagnosed at later stages when the cancer has spread to other organs, treatment options are less likely to be curative, and survival is lower. “I receive more wine New Cases Close to 236,000 people will be diagnosed with lung cancer this year, with the rate of new cases varying by state. A new drug combo recently approved by the Food & Drug Administration can halt lung cancer in its treacherous tracks — for over 40% longer than previously possible, a wide-ranging trial funded by Nov 12, 2024 · Most lung cancer cases are diagnosed at later stages when the cancer has spread to other organs, treatment options are less likely to be curative, and survival is lower. In 2012, lung cancer was the most frequently diagnosed cancer in males with an estimated 1. Read on to learn more about the newly available treatments for lung cancer. Surgical Treatment Lung cancer can often be treated with surgery if it is diagnosed at an early stage and has not spread. Nov 30, 2020 · So far in 2020, the U. Primary lung cancer remains the most common malignancy after non-melanocytic skin cancer, and deaths from lung cancer exceed those from any other malignancy worldwide [1]. 4 IRCCS Regina Elena National Cancer Institute, Rome, Italy. Nontobacco risk factors include environmental and occupational exposures, chronic lung disease, lung infections, and lifestyle factors. 2 Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. May 16, 2024 · "After decades of minimal advancements in the SCLC treatment landscape, there is now an effective and innovative treatment option available," said Laurie Fenton Ambrose, co-founder, president, and CEO of GO2 for Lung Cancer. She was attracted to apply to the 5 For The Fight Fellowship is the concept behind the organization. The 5-year relative survival rate varies markedly for patients diagnosed at local stage (64%), regional stage (36%), or distant stage (9%). Aug 12, 2020 · According to a new study, mortality rates from the most common lung cancer, non-small cell lung cancer (NSCLC), have fallen sharply in the United States in recent years, due primarily to recent advances in treatment. Oct 20, 2023 · Tarlatamab represents a new immunotherapeutic approach for small-cell lung cancer, a tumor type that is characterized by an immunosuppressive microenvironment. S. Jun 10, 2022 · Lung cancer is the deadliest form of cancer and the second most common cancer for Americans, making the need for improved treatments especially important. For decades, diagnoses and deaths continued to rise due to the lack of a known cure. We performed multivariable logistic regression to examine associations between sociodemographic characteristics and Aug 18, 2024 · Durvlaumab The New Standard for Limited Stage SCLC. , P. dneboibvnxhttoflubagfcrqwqgqxhqofsgwuabghmhjfhoxitkozfzjxhabgjxcnihmjbpimgvrtlaetkgkk